Positive Results from First Clinical Study Evaluating A Clinical Target Presented at Major Scientific Meeting

Study data provides an important building block for utilizing NPS technology to treat a variety of benign and non-benign skin lesions, with an 82% clinical efficacy rate for the treatment of seborrheic keratosis lesions

Clinical study findings from two human skin studies using NPS technology were presented at the 2018 American Society for Laser Medicine and Surgery (ASLMS) in Dallas, TX on April 13, 2018. Taken together, these two studies are a foundation for designing future studies for the treatment of benign and non-benign lesions.

The first dose response study of NPS on human skin established an effective range of energy settings for which a unique cellular mechanism of action was observed and established a rationale for efficacy and safety for the treatment of epidermal lesions. ASLMS awarded this study with the Best of Basic Science and Translational Research Award.

The company's first clinical study evaluating NPS for the treatment of a benign skin condition, seborrheic keratosis lesions (SKs), demonstrated positive results for the removal of SK lesions with a single treatment of NPS technology, with a lesion clearance rate of 82% and no adverse events.

This study was given the Best of Basic Science and Translational Research Award by the ASLMS, a worldwide organization dedicated to promoting research, education and high standards of clinical care in the field of medical laser and energy-based applications.

This is the first study of NPS to establish a range of dose-response effect of NPS in human skin and to demonstrate a unique cellular mechanism of action for all of the tested energy levels.

 

Between 2 and 4 hours, Caspase-3 immunohistochemistry marker confirms Programmed Cell Death (PCD)

Between 2 and 4 hours, Caspase-3 immunohistochemistry marker confirms Programmed Cell Death (PCD)

 

By 24 hours, non-thermal cell death with intact cell membranes and minimal fibroplasia

By 24 hours, non-thermal cell death with intact cell membranes, minimal fibroplasia

 

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Multi-center study of NPS treatment of SK lesions, resulting in 82% of treated SK lesions rated as cleared or mostly clear. 

 

Example of cleared SK lesion with clear residual skin

Example of cleared SK lesion with clear residual skin

 

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