Our Technology
Our proprietary Nanosecond Pulsed Field Ablation™ (nsPFA™) technology delivers nanosecond pulses of electrical energy to nonthermally clear cells while sparing adjacent noncellular tissue. nsPFA energy is delivered from the powerful and versatile nsPFA™ generator platform. The nsPFA platform was developed to be capable of connecting to multiple types of applicators from superficial to surgical to catheter-based therapies. Our system has already been used to treat over 6,000 patients safely and effectively outside of Cardiology.
These ultrafast electrical energy pulses have pulse durations from billionths up to a millionth of a second. When applied to targeted tissue, nsPFA energy pulses enter cells and alter the function of the internal cellular organelles, including the mitochondria and endoplasmic reticulum. The cascade of intracellular disruption leads to regulated cell death (RCD). RCD is a process exhibited by cells in the human body when they undergo stress and are unable to restore cellular homeostasis.
Pulse Biosciences has brought to market the first commercial product to harness the distinctive advantages of nsPFA technology.
Mechanism of Action
- Nonthermal modality that delivers nanosecond duration pulses of electrical energy
- Unlike thermal technologies, nsPFA™ energy directly impacts cellular structures while sparing non cellular tissue
- nsPFA™ energy pulses initiate nanopores in cellular membranes that allow ions, such as calcium, to move within the cell
- Triggers a cascade of intracellular disruption that stresses vital cell organelles
- Breakdown of vital cell organelles leads to regulated cell death (RCD)