NPS™ Videos

Tumor response to Nano-Pulse Stimulation™ (NPS) treatment

This animation was created by Pulse Biosciences to illustrate some of the cellular responses to NPS treatment. Immunogenic cell death results in the translocation of calreticulin from the endoplasmic reticulum to the cell surface. Calreticulin is an “eat me” molecule that attracts the dendritic cells to phagocytose the tumor cells and present their antigens to the immune system to mount an immune response against the tumor cells.

The unique nature of NPS technology

Dr. Richard Nuccitelli, Chief Science Officer of Pulse Biosciences, explains NPS pulses and the unique effect these nanosecond pulses have on cells as compared to longer pulse technologies. He describes how this can influence cell functions such as secretion, protein targeting and signal pathways such as regulated cell death.

Nanosecond pulses trigger regulated cell death in cells

Dr. Stephen Beebe, Professor at the Frank Reidy Research Center for Bioelectrics at Old Dominion University, describes how he got involved in using pulsed electric fields in cell signaling and how these nanosecond pulses induce regulated cell death in cells.

Nanosecond electric fields create nanopores in cells

Dr. Tom Vernier, Professor at the Frank Reidy Research Center for Bioelectrics at Old Dominion University, describes how nanosecond electric fields create nanopores in cells through the use of one of his simulations.